Multifaceted Casr

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Publications / Dissemination



The Network will use its website as a key tool for communication amongst the partners and within the Network, as well as to the wider public, scientific, and medical communities. It will advertise the PhD Projects and give details of the training programmes, including Workshops, and Annual Meetings. Summaries of the Annual Meetings, including presentations and supplementary material, will be hosted on the homepage.

As the project is going to undertake top research within its training efforts for ESRs, young researchers will be strongly encouraged to publish at least two papers (as first authors) in one of the top journals of the relevant field. This would be instrumental for ESRs to learn about the rules and principles of scientific publishing and procedures within the scientific community and of course to learn the core basis of how to assist students with their need to order term papers online.

Further, it will be mandatory for ESRs to present their projects at international conferences.

To promote public understanding of science, all researchers of the training network will be encouraged to communicate and disseminate research findings to the widest audience possible including “Children’s Universities” and other international formats fostering “public understanding of science”, e.g. Cheltenham Science Festival, etc.


  • Newsletter Issue No. 1
  • Newsletter Issue No. 2
  • Newsletter Issue No. 3

The Publishable Summary of January 2013 gives an overview of the project and states the main achievements of the first two project  years.

Papers authored by the ESRs

Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels.
Brennan SC, Finney BA, Lazarou M, Rosser AE, Scherf C, Adriaensen D, Kemp PJ, Riccardi D.
PLoS One. 2013 Nov 25;8(11):e80294. doi: 10.1371/journal.pone.0080294. eCollection 2013. PMID: 24282533

The extracellular calcium-sensing receptor, CaSR, in fetal development.
Riccardi D, Brennan SC, Chang W.
Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):443-53. doi: 10.1016/j.beem.2013.02.010. Epub 2013 Mar 26. Review. PMID: 23856271

Calcium sensing receptor signalling in physiology and cancer.
Brennan SC, Thiem U, Roth S, Aggarwal A, Fetahu ISh, Tennakoon S, Gomes AR, Brandi ML, Bruggeman F, Mentaverri R, Riccardi D, Kallay E.
Biochim Biophys Acta. 2013 Jul;1833(7):1732-44. doi: 10.1016/j.bbamcr.2012.12.011. Epub 2012 Dec 23. Review. PMID: 23267858

Mutations affecting G-protein subunit α11 in hypercalcemia and hypocalcemia.
Nesbit MA, Hannan FM, Howles SA, Babinsky VN, Head RA, Cranston T, Rust N, Hobbs MR, Heath H 3rd, Thakker RV.
N Engl J Med. 2013 Jun 27;368(26):2476-86. doi: 10.1056/NEJMoa1300253. PMID: 23802516

Regulation of the calcium-sensing receptor expression by 1,25-dihydroxyvitamin D3, interleukin-6, and tumor necrosis factor alpha in colon cancer cells.
Fetahu IS, Hummel DM, Manhardt T, Aggarwal A, Baumgartner-Parzer S, Kállay E.
J Steroid Biochem Mol Biol. 2013 Oct 28. pii: S0960-0760(13)00208-2. doi: 10.1016/j.jsbmb.2013.10.015. [Epub ahead of print] PMID: 24176760

Role of proinflammatory cytokines on expression of vitamin D metabolism and target genes in colon cancer cells.
Hummel DM, Fetahu IS, Gröschel C, Manhardt T, Kállay E.
J Steroid Biochem Mol Biol. 2013 Oct 9. pii: S0960-0760(13)00191-X. doi: 10.1016/j.jsbmb.2013.09.017. [Epub ahead of print]  PMID: 24120915

Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer.
Höbaus J, Hummel DM, Thiem U, Fetahu IS, Aggarwal A, Müllauer L, Heller G, Egger G, Mesteri I, Baumgartner-Parzer S, Kallay E.
Int J Cancer. 2013 Sep 15;133(6):1380-8. doi: 10.1002/ijc.28143. Epub 2013 Apr 5. PMID: 23463632

Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells.
Höbaus J, Fetahu IS, Khorchide M, Manhardt T, Kallay E.
J Steroid Biochem Mol Biol. 2013 Jul;136:296-9. doi: 10.1016/j.jsbmb.2012.08.003. Epub 2012 Aug 20. PMID: 22940288

Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis.
Hummel DM, Thiem U, Höbaus J, Mesteri I, Gober L, Stremnitzer C, Graça J, Obermayer-Pietsch B, Kallay E.
J Steroid Biochem Mol Biol. 2013 Jul;136:284-8. doi: 10.1016/j.jsbmb.2012.09.003. Epub 2012 Sep 11. PMID: 22982628

Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3.
Fetahu IS, Höbaus J, Aggarwal A, Hummel DM, Tennakoon S, Mesteri I, Baumgartner-Parzer S, Kállay E.
Int J Cancer. 2014 Mar 19. doi: 10.1002/ijc.28856. [Epub ahead of print] PMID: 24691920

Calcimimetics increase CaSR expression and reduce mineralization in vascular smooth muscle cells: mechanisms of action.
Hénaut L, Boudot C, Massy ZA, Lopez-Fernandez I, Dupont S, Mary A, Drüeke TB, Kamel S, Brazier M, Mentaverri R.
Cardiovasc Res. 2014 Feb 1;101(2):256-65. doi: 10.1093/cvr/cvt249. Epub 2013 Nov 11. PMID: 24217682

Vitamin D and the epigenome.
Fetahu IS, Höbaus J, Kállay E.
Front Physiol. 2014 Apr 29;5:164. doi: 10.3389/fphys.2014.00164. eCollection 2014. Review. PMID: 24808866

Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion.
Brennan SC, Davies TS, Schepelmann M, Riccardi D.
Br J Nutr. 2014 Jun;111 Suppl 1:S16-22. Review. PMID: 24382107

The vitamin D system is deregulated in pancreatic diseases.
Hummel D, Aggarwal A, Borka K, Bajna E, Kállay E, Horvath HC.
J Steroid Biochem Mol Biol. 2014 Jul 29. pii: S0960-0760(14)00135-6. doi: 10.1016/j.jsbmb.2014.07.011. [Epub ahead of print]. PMID: 25090635

PTH-C1: a rat continuous cell line expressing the parathyroid phenotype.
Fabbri S, Ciuffi S, Nardone V, Gomes AR, Mavilia C, Zonefrati R, Galli G, Luzi E, Tanini A, Brandi ML.
Endocrine. 2014 Mar 14. [Epub ahead of print] PMID: 24627164

The Calcium-Sensing Receptor: A Promising Target for Prevention of Colorectal Cancer
Abhishek Aggarwal; Maximilian Prinz-Wohlgenannt; Samawansha Tennakoon; Julia Höbaus; Cedric Boudot; Romuald Mentaverri; Edward M Brown; Sabina Baumgartner-Parzer; Enikö Kállay.
Biochim Biophys Acta. 2015 Feb 18. pii: S0167-4889(15)00051-8. doi: 10.1016/j.bbamcr.2015.02.011. [Epub ahead of print].

Allosteric agonists of the calcium receptor (CaR): fluorine and SF5 analogues of cinacalcet.
Chia PW, BRENNAN SC, Slawin AM, RICCARDI D, O'Hagan D.
Org Biomol Chem. 2012 Oct 21;10(39):7922-7.

A conformation-equilibrium model captures ligand-ligand interactions and ligand-biased signalling by G-protein coupled receptors.
S.ROTH & FJ BRUGGEMAN, FEBS J. 2014 Oct;2 81(20):4659-71. doi: 10.1111/febs.12970. Epub 2014 Sep 17.

Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor.
AGGARWAL A, Höbaus J, TENNAKOON S, Prinz-Wohlgenannt M, GRAÇA J, Heffeter P, Berger W, BAUMGARTNER-PARZER S, KÁLLAY E.
Journal of Steroid Biochemistry and Molecular Biology (2015) doi: 10.1016/j.jsbmb.2015.02.06

Association Studies of Calcium-Sensing Receptor (CaSR) Polymorphisms with Serum Concentrations of Glucose and Phosphate, and Vascular Calcification in Renal Transplant Recipients.
BABINSKY VN, HANNAN FM, Youhanna SC, Marécha C, Jadoul M, Devuyst O and THAKKER RV, accepted at PloS One

Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells.
Gröschel C, AGGARWAL A, TENNAKOON S, Höbaus J, Prinz-Wohlgenannt M, Marian B, KALLAY E.
Journal of Steroid Biochemistry and Molecular Biology (2015) doi: 10.1016/j.jsbmb.2015.02.011

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.

Yarova PL, Stewart AL, Sathish V, Britt RD Jr, Thompson MA, P Lowe AP, Freeman M, Aravamudan B, Kita H, BRENNAN SC, SCHEPELMANN M, Davies T, Yung S, Cholisoh Z, Kidd EJ, Ford WR, Broadley KJ, Rietdorf K, Chang W, Bin Khayat ME, Ward DT, Corrigan CJ, T Ward JP, Kemp PJ, Pabelick CM, Prakash YS, RICCARDI D. Sci Transl Med. 2015 Apr 22;7(284):284ra60. doi: 10.1126/scitranslmed.aaa0282. Epub 2015 Apr 22.

The calcium-sensing receptor: one of a kind.
LOPEZ-FERNANDEZ I, SCHEPELMANN M, BRENNAN SC, Yarova PL, RICCARDI D. Exp Physiol. 2015 Jun 23. doi: 10.1113/EP085137.
[Epub ahead of print]

Impact of CYP24A1 overexpression on growth of colorectal tumour xenografts in mice fed with vitamin D and soy.
Höbaus J, TENNAKOON S, Heffeter P, Groeschel C, AGGARWAL A, Hummel DM, Thiem U, Marculescu R, Berger W, KÁLLAY E. Int J Cancer. 2015 Aug 3. doi: 10.1002/ijc.29717. [Epub ahead of print]

The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon.
A, PRINZ-WOHLGENANNT M, Gröschel C, TENNAKOON S, Meshcheryakova A, Chang W, BROWN EM, Mechtcheriakova D, KÁLLAY E. Mol Cancer. 2015 Mar 18;14:61. doi: 10.1186/s12943-015-0330-4.

miR-135b- and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors.
FETAHU IS, TENNAKOON S, Lines KE, Gröschel C, AGGARWAL A, Mesteri I, BAUMGARTNER-PARZER S, Mader RM, THAKKER RV, KÁLLAY E. Int J Cancer. 2015 Jul 14. doi: 10.1002/ijc.29681. [Epub ahead of print]

The calcium-sensing receptor: A promising target for prevention of colorectal cancer.
A, PRINZ-WOHLGENANNT M, TENNAKOON S, Höbaus J, Boudot C, MENTAVERRI R, BROWN EM, BAUMGARTNER-PARZER S, KÁLLAY E. Biochim Biophys Acta. 2015 Sep;1853(9):2158-67. doi: 10.1016/j.bbamcr.2015.02.011. Epub 2015 Feb 18.

G Protein-Coupled Receptor Signaling Networks from a Systems Perspective.
ROTH S, Kholodenko BN, Smit MJ, BRUGGEMAN FJ. Mol Pharmacol. 2015 Sep;88(3):604-16. doi: 10.1124/mol.115.100057. Epub 2015 Jul 10.

Effects of the calcimimetic R-568 in mouse vascular smooth muscle cells.
T. Davies, M. SCHEPELMANN, SC. BRENNAN, P. Yarova, W. Chang, D. Bikle, W. Richards, D. T Ward, A. E Canfield, D. Edwards, P. KEMP, and D. RICCARDI.  Submitted.

Submitted/Imminent submission

M Schepelmann, P.L. Yarova, I. Lopez-Fernandez, T.S. Davies, S.C. Brennan, P.J. Ed-wards, A. Aggarwal, K. Rietdorf, V. Matchkov, R.A. Fenton,
W. Chang, M. Krssak, A. Stewart, K.J. Broadley, D.T. Ward, S.A. Price, D.H. Edwards, P.J. Kemp and D. Ric-cardi. The vascular Ca2+-sensing receptor is involved in regulation of blood pressure and blood vessel tone. Circulation Research.

SC Brennan, WJ Wilkinson, M Schepelmann, H-E Tseng, B Monk, S Quilliam, H Dib-ble, L Galietta, PJ Kemp, D Riccardi. The calcium-sensing receptor regulates fetal lung development through CFTR. Molecular Cell Biology.


Multifaceted CaSR is a Marie Curie Action
funded by the European Commission
under the 7th Framework Programme

Official Sponsors of the 1st CaSR Symposium

Sponsors of the first CaSR Symposium





Flyer 3rd Symposium on CaSR